USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P05121 USC-OGP 2-DE database:  P05121 P05121 General information about the entry View entry in simple text format Entry name PAI1_HUMAN Primary accession number P05121 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Plasminogen activator inhibitor 1; Short=PAI; Short=PAI-1; AltName: Full=Endothelial plasminogen activator inhibitor; AltName: Full=Serpin E1; Flags: Precursor;. Gene name Name=SERPINE1 Synonyms=PAI1, PLANH1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0393: pI=6.69; Mw=45326 Cross-references UniProtKB/Swiss-Prot P05121; PAI1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PAI1_HUMAN Primary accession number P05121 Secondary accession number(s) B7Z4S0 F8WD53 Sequence was last modified on  August 13, 1987 (version 1) Annotations were last modified on  March 15, 2017 (version 206) Name and origin of the protein Description RecName: Full=Plasminogen activator inhibitor 1; Short=PAI; Short=PAI-1; AltName: Full=Endothelial plasminogen activator inhibitor; AltName: Full=Serpin E1; Flags: Precursor; Gene name Name=SERPINE1 Synonyms=PAI1, PLANH1 Encoded on Name=SERPINE1; Synonyms=PAI1, PLANH1 Keywords 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Glycoprotein; Polymorphism; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X04429; CAA28025.1; -; mRNA EMBL M14083; AAA60008.1; -; mRNA EMBL X04729; CAA28438.1; -; mRNA EMBL X04731; CAA28442.1; -; mRNA EMBL M16006; AAA60003.1; -; mRNA EMBL M22321; AAA60009.1; -; Genomic_DNA EMBL M22314; AAA60009.1; JOINED; Genomic_DNA EMBL M22315; AAA60009.1; JOINED; Genomic_DNA EMBL M22316; AAA60009.1; JOINED; Genomic_DNA EMBL M22317; AAA60009.1; JOINED; Genomic_DNA EMBL M22318; AAA60009.1; JOINED; Genomic_DNA EMBL M22319; AAA60009.1; JOINED; Genomic_DNA EMBL M22320; AAA60009.1; JOINED; Genomic_DNA EMBL X13323; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL X13338; CAA31722.1; -; Genomic_DNA EMBL X13339; CAB51639.1; -; Genomic_DNA EMBL X13340; CAB51737.1; -; Genomic_DNA EMBL X13341; CAB51606.1; -; Genomic_DNA EMBL X13342; CAB51607.1; -; Genomic_DNA EMBL X13343; CAB51738.1; -; Genomic_DNA EMBL X13344; CAB51739.1; -; Genomic_DNA EMBL X13345; CAA31729.1; -; Genomic_DNA EMBL J03764; AAA60007.1; -; Genomic_DNA EMBL X12701; CAA31208.1; -; mRNA EMBL AF386492; AAK60338.1; -; Genomic_DNA EMBL AK297728; BAH12656.1; -; mRNA EMBL AC004876; AAD45828.1; -; Genomic_DNA EMBL BC010860; AAH10860.1; -; mRNA EMBL X04744; CAA28444.1; -; mRNA CCDS CCDS5711.1; -. [P05121-1]; . PIR A28107; ITHUP1; . RefSeq NP_000593.1; NM_000602.4. [P05121-1]; . UniGene Hs.414795; -; . UniGene Hs.713079; -; . UniGene Hs.741440; -; . PDB 1A7C; X-ray; 1.95 A; A=24-402 PDB 1B3K; X-ray; 2.99 A; A/B/C/D=24-402 PDB 1C5G; X-ray; 2.60 A; A=1-402 PDB 1DB2; X-ray; 2.70 A; A/B=26-402 PDB 1DVM; X-ray; 2.40 A; A/B/C/D=24-402 PDB 1DVN; X-ray; 2.10 A; A=24-402 PDB 1LJ5; X-ray; 1.80 A; A=24-402 PDB 1OC0; X-ray; 2.28 A; A=24-402 PDB 3CVM; X-ray; 2.02 A; A/B=21-402 PDB 3EOX; X-ray; 2.61 A; A=24-402 PDB 3PB1; X-ray; 2.30 A; I=24-402 PDB 3Q02; X-ray; 2.30 A; A/B=24-402 PDB 3Q03; X-ray; 2.64 A; A/B=24-402 PDB 3R4L; X-ray; 2.70 A; A=24-402 PDB 3UT3; X-ray; 2.42 A; A/B/C/D=28-402 PDB 4AQH; X-ray; 2.40 A; A/B/C=24-402 PDB 4G8O; X-ray; 2.71 A; A/B/C/D=28-402 PDB 4G8R; X-ray; 2.19 A; A/B=28-402 PDB 4IC0; X-ray; 2.32 A; A/B/C/D=24-402 PDB 5BRR; X-ray; 3.16 A; I=24-402 PDB 9PAI; X-ray; 2.70 A; A=24-369 B=370-402 PDBsum; 1A7C; -; . PDBsum 1B3K; -; . PDBsum 1C5G; -; . PDBsum 1DB2; -; . PDBsum 1DVM; -; . PDBsum 1DVN; -; . PDBsum 1LJ5; -; . PDBsum 1OC0; -; . PDBsum 3CVM; -; . PDBsum 3EOX; -; . PDBsum 3PB1; -; . PDBsum 3Q02; -; . PDBsum 3Q03; -; . PDBsum 3R4L; -; . PDBsum 3UT3; -; . PDBsum 4AQH; -; . PDBsum 4G8O; -; . PDBsum 4G8R; -; . PDBsum 4IC0; -; . PDBsum 5BRR; -; . PDBsum 9PAI; -; . DisProt DP00320; -; . ProteinModelPortal P05121; -; . SMR P05121; -; . BioGrid 111091; 16; . IntAct P05121; 13; . MINT MINT-202409; -; . STRING 9606.ENSP00000223095; -; . BindingDB P05121; -; . ChEMBL CHEMBL3475; -; . DrugBank DB00009; Alteplase; . DrugBank DB00029; Anistreplase; . DrugBank DB00055; Drotrecogin alfa; . DrugBank DB05254; Plasmin; . DrugBank DB00015; Reteplase; . DrugBank DB00031; Tenecteplase; . DrugBank DB00197; Troglitazone; . DrugBank DB00013; Urokinase; . MEROPS I04.020; -; . iPTMnet P05121; -; . PhosphoSitePlus P05121; -; . UniCarbKB P05121; -; . BioMuta SERPINE1; -; . DMDM 129576; -; . OGP P05121; -; . SWISS-2DPAGE P05121; -; . EPD P05121; -; . MaxQB P05121; -; . PaxDb P05121; -; . PeptideAtlas P05121; -; . PRIDE P05121; -; . DNASU 5054; -; . Ensembl ENST00000223095; ENSP00000223095; ENSG00000106366. [P05121-1]; . GeneID 5054; -; . KEGG hsa:5054; -; . UCSC uc003uxt.4; human. [P05121-1]; . CTD 5054; -; . DisGeNET 5054; -; . GeneCards SERPINE1; -; . HGNC HGNC:8583; SERPINE1; . HPA HPA050039; -; . MalaCards SERPINE1; -; . MIM 173360; gene; . MIM 613329; phenotype; . neXtProt NX_P05121; -; . OpenTargets ENSG00000106366; -; . Orphanet 465; Congenital plasminogen activator inhibitor type 1 deficiency; . PharmGKB PA261; -; . eggNOG KOG2392; Eukaryota; . eggNOG COG4826; LUCA; . GeneTree ENSGT00760000118839; -; . HOGENOM HOG000238519; -; . HOVERGEN HBG106493; -; . InParanoid P05121; -; . KO K03982; -; . OMA IVNDWVK; -; . OrthoDB EOG091G0ION; -; . PhylomeDB P05121; -; . TreeFam TF352620; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-1368108; BMAL1:CLOCK; NPAS2 activates circadian gene expression; . Reactome R-HSA-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; . Reactome R-HSA-3000178; ECM proteoglycans; . Reactome R-HSA-75205; Dissolution of Fibrin Clot; . SIGNOR P05121; -; . ChiTaRS SERPINE1; human; . EvolutionaryTrace P05121; -; . GeneWiki Plasminogen_activator_inhibitor-1; -; . GenomeRNAi 5054; -; . PMAP-CutDB P05121; -; . PRO PR:P05121; -; . Proteomes UP000005640; Chromosome 7; . Bgee ENSG00000106366; -; . CleanEx HS_SERPINE1; -; . ExpressionAtlas P05121; baseline and differential; . Genevisible P05121; HS; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005576; C:extracellular region; IDA:BHF-UCL; . GO GO:0005615; C:extracellular space; IDA:BHF-UCL; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . GO GO:0002020; F:protease binding; IPI:UniProtKB; . GO GO:0005102; F:receptor binding; IPI:BHF-UCL; . GO GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:BHF-UCL; . GO GO:0001525; P:angiogenesis; IEP:UniProtKB; . GO GO:0071222; P:cellular response to lipopolysaccharide; IMP:BHF-UCL; . GO GO:0001300; P:chronological cell aging; IEP:BHF-UCL; . GO GO:0007623; P:circadian rhythm; TAS:Reactome; . GO GO:0050829; P:defense response to Gram-negative bacterium; IGI:BHF-UCL; . GO GO:0030198; P:extracellular matrix organization; TAS:Reactome; . GO GO:0042730; P:fibrinolysis; TAS:Reactome; . GO GO:0030195; P:negative regulation of blood coagulation; IC:BHF-UCL; . GO GO:0033629; P:negative regulation of cell adhesion mediated by integrin; IDA:BHF-UCL; . GO GO:0030336; P:negative regulation of cell migration; IDA:BHF-UCL; . GO GO:0010951; P:negative regulation of endopeptidase activity; IDA:BHF-UCL; . GO GO:2000352; P:negative regulation of endothelial cell apoptotic process; IMP:BHF-UCL; . GO GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IMP:BHF-UCL; . GO GO:0051918; P:negative regulation of fibrinolysis; IDA:BHF-UCL; . GO GO:0010757; P:negative regulation of plasminogen activation; IDA:BHF-UCL; . GO GO:0014912; P:negative regulation of smooth muscle cell migration; IDA:BHF-UCL; . GO GO:2000098; P:negative regulation of smooth muscle cell-matrix adhesion; IDA:BHF-UCL; . GO GO:0061044; P:negative regulation of vascular wound healing; IGI:BHF-UCL; . GO GO:0061045; P:negative regulation of wound healing; IC:BHF-UCL; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0045766; P:positive regulation of angiogenesis; IMP:BHF-UCL; . GO GO:0030194; P:positive regulation of blood coagulation; IMP:BHF-UCL; . GO GO:0050729; P:positive regulation of inflammatory response; IGI:BHF-UCL; . GO GO:0032757; P:positive regulation of interleukin-8 production; IMP:BHF-UCL; . GO GO:0035491; P:positive regulation of leukotriene production involved in inflammatory response; IMP:BHF-UCL; . GO GO:0090026; P:positive regulation of monocyte chemotaxis; IMP:BHF-UCL; . GO GO:0048260; P:positive regulation of receptor-mediated endocytosis; IDA:BHF-UCL; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; TAS:Reactome; . GO GO:0010469; P:regulation of receptor activity; IDA:BHF-UCL; . InterPro IPR023795; Serpin_CS; . InterPro IPR023796; Serpin_dom; . InterPro IPR000215; Serpin_fam; . PANTHER PTHR11461; PTHR11461; 1; . Pfam PF00079; Serpin; 1; . SMART SM00093; SERPIN; 1; . SUPFAM SSF56574; SSF56574; 1; . PROSITE PS00284; SERPIN; 1; .

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